The importance of hypoxia in radiotherapy for the immune response, metastatic potential and FLASH-RT.
Int J Radiat Biol
; 98(3): 439-451, 2022.
Article
em En
| MEDLINE
| ID: mdl-34726575
ABSTRACT
PURPOSE:
Hypoxia (low oxygen) is a common feature of solid tumors that has been intensely studied for more than six decades. Here we review the importance of hypoxia to radiotherapy with a particular focus on the contribution of hypoxia to immune responses, metastatic potential and FLASH radiotherapy, active areas of research by leading women in the field.CONCLUSION:
Although hypoxia-driven metastasis and immunosuppression can negatively impact clinical outcome, understanding these processes can also provide tumor-specific vulnerabilities that may be therapeutically exploited. The different oxygen tensions present in tumors and normal tissues may underpin the beneficial FLASH sparing effect seen in normal tissue and represents a perfect example of advances in the field that can leverage tumor hypoxia to improve future radiotherapy treatments.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Radioterapia (Especialidade)
/
Neoplasias
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article