Assessing the Safety of a Novel Neonatal Anesthesia Protocol: A Review of 101 Patients With Early Cleft Lip Repair.
J Craniofac Surg
; 32(8): 2682-2686, 2021.
Article
em En
| MEDLINE
| ID: mdl-34727471
ABSTRACT
PURPOSE:
Our study introduces a novel anesthetic protocol for neonates without using volatile agents with the goal to minimize potentially neurotoxic and pro-apoptotic agents. The authors evaluated the short-term safety and efficacy of our anesthetic protocol in patients undergoing early cleft lip repair (ECLR).METHODS:
A retrospective review of ECLR patients who underwent repair before 2.5âmonths of age within the last 4.3âyears was performed. This sample was comprised of 2 groups, those who received either a standard volatile gas-based regimen or a dexmedetomidine-based neonatal anesthetic protocol (DBNAP). Patient demographics, medication dosing, anesthetic time (induction to extubation), major and minor complications, and medication side effects were compared between the 2 cohorts.RESULTS:
A total of 101 patients underwent ECLR. All patients were American Society of Anesthesiologists class 1 or 2. Mean age at surgery was 31â±â13âdays and mean anesthetic time was 179â±â36âminutes. DBNAP was used in 65 patients while the standard anesthetic protocol was used in 36 patients. Patient weight was significantly lower in the DBNAP group (4.01â±â0.61 versus 4.38â±â0.72âkg, Pâ =â0.007). There were no significant differences between the 2 cohorts when comparing anesthetic time, emergence time, complication rate, or medication side effects.CONCLUSION:
For patients undergoing ECLR, DBNAP is perioperatively equivalent to the anesthetic standard of care, demonstrating no major complications and acceptable rates of minor complications and medication side effects.
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Base de dados:
MEDLINE
Assunto principal:
Fenda Labial
/
Anestesia Dentária
/
Anestésicos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article