A hypothetical skin sensitisation next generation risk assessment for coumarin in cosmetic products.

Reynolds, G; Reynolds, J; Gilmour, N; Cubberley, R; Spriggs, S; Aptula, A; Przybylak, K; Windebank, S; Maxwell, G; Baltazar, M T

Reynolds, G; Reynolds, J; Gilmour, N; Cubberley, R; Spriggs, S; Aptula, A; Przybylak, K; Windebank, S; Maxwell, G; Baltazar, M T.

Afiliação

Reynolds G; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK. Electronic address: georgia.reynolds@unilever.com.
Reynolds J; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK.
Gilmour N; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK.
Cubberley R; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK.
Spriggs S; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK.
Aptula A; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK.
Przybylak K; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK.
Windebank S; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK.
Maxwell G; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK.
Baltazar MT; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK. Electronic address: maria.baltazar@unilever.com.

Regul Toxicol Pharmacol ; 127: 105075, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34728330

Assuntos

Teorema de Bayes; Cosméticos/toxicidade; Cumarínicos/toxicidade; Dermatite de Contato/patologia; Modelos Teóricos; Alternativas aos Testes com Animais; Técnicas de Cultura de Células; Sistema Enzimático do Citocromo P-450/efeitos dos fármacos; Fígado/efeitos dos fármacos; Medição de Risco; Testes de Irritação da Pele

Palavras-chave

Allergic contact dermatitis; Consumer exposure; Decision making; Metabolism; New approach methodologies; Next generation risk assessment; Non-animal alternatives; Skin sensitisation; Uncertainty analysis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Teorema de Bayes / Cosméticos / Cumarínicos / Dermatite de Contato / Modelos Teóricos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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