AKT, Akt serine/threonine kinase; Bacteria-mediated cancer therapy; CFU, colony-forming units; CTLA-4, cytotoxic T-lymphocyte-associated protein 4; Cancer immune therapy; DN, dominant-negative; ERBB2, Erb-B2 receptor tyrosine kinase 2; ERKl, extracellular regulated protein kinase 1; Flagellin; Flagellum; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GFP, green fluorescent protein; IFN-γ, interferon-γ; IL, interleukins; IκB, inhibitor of NF-κB; JNK, c-Jun N-terminal kinase; LPS, lipopolysaccharide; LRR, leucine-rich repeat; MyD88, myeloid differentiation factor 88; NF-κB; NF-κB, nuclear factor kappa-B; PBS, phosphate-buffered saline; PCR, polymerase chain reaction; PD-1, programmed cell death protein-1; PD-L1, programmed cell death-ligand 1; PEI, polyethylenimine; Salmonella; TIR, Toll/Interleukin-1 receptor; TLR, Toll-like receptor; TLR5; TME, tumor microenvironment; TRAF6, TNF receptor associated factor 6; VNP20009; i.p., intraperitoneally; i.t., intratumorally