K2S2O8-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones.
Org Biomol Chem
; 19(44): 9758-9772, 2021 11 18.
Article
em En
| MEDLINE
| ID: mdl-34730163
ABSTRACT
We herein present the synthesis of diversely functionalized pyrimidine fused thiazolino-2-pyridones via K2S2O8-mediated oxidative coupling of 6-amino-7-(aminomethyl)-thiazolino-2-pyridones with aldehydes. The developed protocol is mild, has wide substrate scope, and does not require transition metal catalyst or base. Some of the synthesized compounds have an ability to inhibit the formation of Amyloid-ß fibrils associated with Alzheimer's disease, while others bind to mature amyloid-ß and α-synuclein fibrils.
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Base de dados:
MEDLINE
Assunto principal:
Aldeídos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article