Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice.
Cell Rep
; 37(5): 109936, 2021 11 02.
Article
em En
| MEDLINE
| ID: mdl-34731609
ABSTRACT
Depression symptoms are often found in patients suffering from chronic pain, a phenomenon that is yet to be understood mechanistically. Here, we systematically investigate the cellular mechanisms and circuits underlying the chronic-pain-induced depression behavior. We show that the development of chronic pain is accompanied by depressive-like behaviors in a mouse model of trigeminal neuralgia. In parallel, we observe increased activity of the dopaminergic (DA) neuron in the midbrain ventral tegmental area (VTA), and inhibition of this elevated VTA DA neuron activity reverses the behavioral manifestations of depression. Further studies establish a pathway of glutamatergic projections from the spinal trigeminal subnucleus caudalis (Sp5C) to the lateral parabrachial nucleus (LPBN) and then to the VTA. These glutamatergic projections form a direct circuit that controls the development of the depression-like behavior under the state of the chronic neuropathic pain.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neuralgia do Trigêmeo
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Comportamento Animal
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Área Tegmentar Ventral
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Depressão
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Dor Crônica
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Núcleos Parabraquiais
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article