Relating cellular signaling timescales to single-molecule kinetics: A first-passage time analysis of Ras activation by SOS.

Huang, William Y C; Alvarez, Steven; Kondo, Yasushi; Kuriyan, John; Groves, Jay T

Huang, William Y C; Alvarez, Steven; Kondo, Yasushi; Kuriyan, John; Groves, Jay T.

Afiliação

Huang WYC; Department of Chemistry, University of California, Berkeley, CA 94720.
Alvarez S; Department of Materials Science and Engineering, University of California, Berkeley, CA 94720.
Kondo Y; Department of Chemistry, University of California, Berkeley, CA 94720.
Kuriyan J; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Groves JT; California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720.

Proc Natl Acad Sci U S A ; 118(45)2021 11 09.

Article em En | MEDLINE | ID: mdl-34740968

Assuntos

Modelos Químicos; Proteínas Son Of Sevenless/metabolismo; Proteínas ras/metabolismo; Ativação Enzimática; Cinética; Imagem Individual de Molécula

Palavras-chave

MAPK; Ras; activation timing; first-passage time; signal transduction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas ras / Proteínas Son Of Sevenless / Modelos Químicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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