Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.

Wang, Jingjing; Su, Qi; Wu, Qing; Chen, Kun; Ullah, Asmat; Ghauri, Mohsin Ahmad; Zhang, Yanmin

Wang, Jingjing; Su, Qi; Wu, Qing; Chen, Kun; Ullah, Asmat; Ghauri, Mohsin Ahmad; Zhang, Yanmin.

Afiliação

Wang J; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, No.76, Yanta West Street, #54, Xi'an, 710061, Shaanxi Province, People's Republic of China.
Su Q; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, No.76, Yanta West Street, #54, Xi'an, 710061, Shaanxi Province, People's Republic of China.
Wu Q; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, No.76, Yanta West Street, #54, Xi'an, 710061, Shaanxi Province, People's Republic of China.
Chen K; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, No.76, Yanta West Street, #54, Xi'an, 710061, Shaanxi Province, People's Republic of China.
Ullah A; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, No.76, Yanta West Street, #54, Xi'an, 710061, Shaanxi Province, People's Republic of China.
Ghauri MA; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, No.76, Yanta West Street, #54, Xi'an, 710061, Shaanxi Province, People's Republic of China.
Zhang Y; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, No.76, Yanta West Street, #54, Xi'an, 710061, Shaanxi Province, People's Republic of China. zhang2008@mail.xjtu.edu.cn.

Arch Pharm Res ; 44(11): 1025-1036, 2021 Nov.

Article em En | MEDLINE | ID: mdl-34751932

Assuntos

Benzofenantridinas/farmacologia; Carcinoma Hepatocelular/tratamento farmacológico; Isoquinolinas/farmacologia; Neoplasias Hepáticas/tratamento farmacológico; Animais; Apoptose/efeitos dos fármacos; Benzofenantridinas/uso terapêutico; Carcinoma Hepatocelular/patologia; Linhagem Celular Tumoral; Humanos; Isoquinolinas/uso terapêutico; Neoplasias Hepáticas/patologia; Lisossomos/efeitos dos fármacos; Camundongos; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/patologia; Mitofagia/efeitos dos fármacos; Espécies Reativas de Oxigênio/agonistas; Espécies Reativas de Oxigênio/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Apoptosis; Hepatocellular carcinoma; Lysosomal function; Mitophagy; Reactive oxygen species; Sanguinarine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Benzofenantridinas / Isoquinolinas / Neoplasias Hepáticas Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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