Immunomodulatory Response of Toll-like Receptor Ligand-Peptide Conjugates in Food Allergy.
ACS Chem Biol
; 16(11): 2651-2664, 2021 11 19.
Article
em En
| MEDLINE
| ID: mdl-34761908
ABSTRACT
Covalent conjugation of allergens to toll-like receptor (TLR) agonists appears to be a powerful strategy for the development of safety compounds for allergen-specific immunomodulatory response toward tolerance in allergy. In this work, we have synthesized two family of ligands, an 8-oxoadenine derivative as a ligand for TLR7 and a pyrimido[5,4-b]indole as a ligand for TLR4, both conjugated with a T-cell peptide of Pru p 3 allergen, the lipid transfer protein (LTP) responsible for LTP-dependent food allergy. These conjugates interact with dendritic cells, inducing their specific maturation, T-cell proliferation, and cytokine production in peach allergic patients. Moreover, they increased the Treg-cell frequencies in these patients and could induce the IL-10 production. These outcomes were remarkable in the case of the TLR7 ligand conjugated with Pru p 3, opening the door for the potential application of these allergen-adjuvant systems in food allergy immunotherapy.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Receptor 4 Toll-Like
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Receptor 7 Toll-Like
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Imunomodulação
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Hipersensibilidade Alimentar
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article