Precursor-Directed Biosynthesis of Talaroenamine Derivatives Using a Yellow River Wetland-Derived Penicillium malacosphaerulum.
J Nat Prod
; 84(11): 2923-2928, 2021 11 26.
Article
em En
| MEDLINE
| ID: mdl-34762445
ABSTRACT
Precursor-directed biosynthesis was used to introduce selected aniline derivatives into the talaroenamine pathway, which had recently been defined from a Yellow River wetland-derived Penicillim malacosphaerulum HPU-J01. The known talaroenamine B (1) and six previously undescribed talaroenamine derivatives, talaroenamines F-K (2-7), were generated and structurally characterized. The aniline derivatives are introduced via nonenzymatic addition to the reactive intermediate cyclohexanedione. Compound 2 was active against Bacillus cereus with an MIC value of 0.85 µg/mL.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Penicillium
/
Aminas
/
Compostos de Anilina
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article