Neutrophilic inflammation in gallbladder carcinoma correlates with patient survival: A case-control study.
Ann Diagn Pathol
; 56: 151845, 2022 Feb.
Article
em En
| MEDLINE
| ID: mdl-34763224
ABSTRACT
Gallbladder carcinoma is an uncommon malignancy with an overall 5-year survival of less than 5%. Gallbladder carcinoma has been strongly linked with cholelithiasis and chronic inflammation. Case reports and series have described cholecystitis with acute (neutrophilic) inflammation in association with gallbladder carcinoma, although a clear relationship to patient outcome has not been established. Our series included 8 cases of gallbladder carcinoma with high tumor-associated neutrophils (>25 per high power field) that were associated with shorter patient survival (Cox regression coefficient 6.2, p = 0.004) than age- and stage-matched controls. High tumor-associated neutrophils were not associated with gallbladder rupture/perforation or increased bacterial load measured by 16S PCR. Neutrophilic inflammation with gallbladder carcinoma correlates to shorter survival, independent of patient age and stage of carcinoma. The findings suggest that the degree of neutrophilic inflammation may have prognostic significance in specimens from patients with gallbladder carcinoma after cholecystectomy. Further studies with larger case numbers are needed to confirm and generalize these findings.
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Base de dados:
MEDLINE
Assunto principal:
Colecistite
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Infiltração de Neutrófilos
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Vesícula Biliar
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Neoplasias da Vesícula Biliar
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article