Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus.
Trends Immunol
; 42(12): 1054-1056, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-34764015
ABSTRACT
Type 1 interferon (IFN) is a major contributor to the pathogenesis of systemic lupus erythematosus (SLE). A landmark study by Caielli et al. now shows that erythrocytes from lupus patients that fail to switch from glycolysis to oxidative phosphorylation during differentiation retain their mitochondria. These mitochondria-containing erythrocytes represent a novel source of IFN when phagocytosed by macrophages.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Interferon Tipo I
/
Lúpus Eritematoso Sistêmico
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article