Protein abundance and folding rather than the redox state of Kelch13 determine the artemisinin susceptibility of Plasmodium falciparum.

Schumann, Robin; Bischoff, Eileen; Klaus, Severina; Möhring, Sophie; Flock, Julia; Keller, Sandro; Remans, Kim; Ganter, Markus; Deponte, Marcel.

Afiliação

Schumann R; Faculty of Chemistry, Comparative Biochemistry, Technische Universität Kaiserslautern, D-67663 Kaiserslautern, Germany.
Bischoff E; Faculty of Chemistry, Comparative Biochemistry, Technische Universität Kaiserslautern, D-67663 Kaiserslautern, Germany.
Klaus S; Centre for Infectious Diseases, Parasitology, Heidelberg University Hospital, D-69120, Heidelberg, Germany.
Möhring S; Faculty of Chemistry, Comparative Biochemistry, Technische Universität Kaiserslautern, D-67663 Kaiserslautern, Germany.
Flock J; Protein Expression and Purification Core Facility, European Molecular Biology Laboratory (EMBL), D-69117, Heidelberg, Germany.
Keller S; Molecular Biophysics, Technische Universität Kaiserslautern, D-67663, Kaiserslautern, Germany; Biophysics, Institute of Molecular Biosciences (IMB), NAWI Graz, University of Graz, Humboldtstr. 50/III, 8010, Graz, Austria; Field of Excellence BioHealth, University of Graz, Graz, Austria; BioTechMed-G
Remans K; Protein Expression and Purification Core Facility, European Molecular Biology Laboratory (EMBL), D-69117, Heidelberg, Germany.
Ganter M; Centre for Infectious Diseases, Parasitology, Heidelberg University Hospital, D-69120, Heidelberg, Germany.
Deponte M; Faculty of Chemistry, Comparative Biochemistry, Technische Universität Kaiserslautern, D-67663 Kaiserslautern, Germany. Electronic address: deponte@chemie.uni-kl.de.