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A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use-The P5 Study.
Marjonen, Heidi; Marttila, Minttu; Paajanen, Teemu; Vornanen, Marleena; Brunfeldt, Minna; Joensuu, Anni; Halmesvaara, Otto; Aro, Kimmo; Alanne-Kinnunen, Mervi; Jousilahti, Pekka; Borodulin, Katja; Koskinen, Seppo; Tuomi, Tiinamaija; Ilanne-Parikka, Pirjo; Lindström, Jaana; Laine, Merja K; Auro, Kirsi; Kääriäinen, Helena; Perola, Markus; Kristiansson, Kati.
Afiliação
  • Marjonen H; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Marttila M; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Paajanen T; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Vornanen M; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Brunfeldt M; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Joensuu A; Department of Social Research, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland.
  • Halmesvaara O; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Aro K; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Alanne-Kinnunen M; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Jousilahti P; Department of Social Research, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland.
  • Borodulin K; Negen Ltd., Helsinki, Finland.
  • Koskinen S; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Tuomi T; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Ilanne-Parikka P; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Lindström J; Age Institute, Helsinki, Finland.
  • Laine MK; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Auro K; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Kääriäinen H; Abdominal Centre, Endocrinology, Helsinki University Hospital, Helsinki, Finland.
  • Perola M; Folkhälsan Research Centre, Helsinki, Finland.
  • Kristiansson K; Institute for Molecular Medicine Finland, Helsinki, Finland.
Front Genet ; 12: 763159, 2021.
Article em En | MEDLINE | ID: mdl-34777479
ABSTRACT
We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person's future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article