Robust thrombolytic and anti-inflammatory action of a constitutively active ADAMTS13 variant in murine stroke models.

South, Kieron; Saleh, Ohud; Lemarchand, Eloise; Coutts, Graham; Smith, Craig J; Schiessl, Ingo; Allan, Stuart M

South, Kieron; Saleh, Ohud; Lemarchand, Eloise; Coutts, Graham; Smith, Craig J; Schiessl, Ingo; Allan, Stuart M.

Afiliação

South K; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Saleh O; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance National Health Service (NHS) Group-University of Manchester, Manchester, United Kingdom.
Lemarchand E; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Coutts G; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance National Health Service (NHS) Group-University of Manchester, Manchester, United Kingdom.
Smith CJ; Department of Biochemistry, Faculty of Sciences, University of Jeddah, Jeddah, Saudi Arabia.
Schiessl I; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Allan SM; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance National Health Service (NHS) Group-University of Manchester, Manchester, United Kingdom.

Blood ; 139(10): 1575-1587, 2022 03 10.

Article em En | MEDLINE | ID: mdl-34780600

Assuntos

AVC Isquêmico; Acidente Vascular Cerebral; Proteína ADAMTS13/genética; Animais; Anti-Inflamatórios/uso terapêutico; Fibrina; Fibrinolíticos/uso terapêutico; Infarto da Artéria Cerebral Média/patologia; Camundongos; Acidente Vascular Cerebral/tratamento farmacológico; Fator de von Willebrand/uso terapêutico

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acidente Vascular Cerebral / AVC Isquêmico Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acidente Vascular Cerebral / AVC Isquêmico Idioma: En Ano de publicação: 2022 Tipo de documento: Article