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Creatinine-to-cystatin C ratio estimates muscle mass correlating the markers of the patients with severe motor and intellectual disabilities.
Nakahara, Hirotomo; Hashizume, Naoki; Yoshida, Motomu; Fukahori, Suguru; Ishii, Shinji; Saikusa, Nobuyuki; Koga, Yoshinori; Higashidate, Naruki; Sakamoto, Saki; Tsuruhisa, Shiori; Tanaka, Yoshiaki; Yamashita, Yushiro; Yagi, Minoru.
Afiliação
  • Nakahara H; Department of Pediatric Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Hashizume N; Department of Pediatric Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan. Electronic address: hashidume_naoki@med.kurume-u.ac.jp.
  • Yoshida M; Department of Pediatric Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Fukahori S; Department of Pediatric Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Ishii S; Department of Pediatric Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Saikusa N; Department of Pediatric Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Koga Y; Department of Pediatric Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Higashidate N; Department of Pediatric Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Sakamoto S; Department of Pediatric Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Tsuruhisa S; Department of Pediatric Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Tanaka Y; Department of Pediatric Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan; Division of Medical Safety Management, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Yamashita Y; Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Yagi M; Department of Pediatric Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Brain Dev ; 44(3): 196-202, 2022 Mar.
Article em En | MEDLINE | ID: mdl-34782198
ABSTRACT

AIM:

The creatinine-to-cystatin C ratio (CCR) has been acknowledged as a potential marker of muscle mass. The purpose of the present study was to evaluate the relationship between CCR and nutritional status in a bioelectrical impedance analysis (BIA) of patients with severe motor and intellectual disabilities (SMID).

METHODS:

This study included 39 patients with SMID (17 males, 22 females) over 16 years of age were included retrospectively. CCR was calculated as serum creatinine (mg/dL)/cystatin C (mg/L) × 10. The BIA parameters such as the phase angle (PhA), fat free mass (FFM), appendicular skeletal muscle mass (ASM) and appendicular skeletal muscle mass index (ASMI) values were measured using BIA. Correlation analyses between CCR and the BIA parameters were conducted.

RESULTS:

The mean CCR is 4.47 ±â€¯1.34. Significant positive relationships between CCR and FFM, PhA, ASM, ASMI were identified (r = 0.3373, p = 0.0357. r = 0.4273, p = 0.0093. r = 0.5008, p = 0.0012. r = 0.4706, p = 0.0025 and r = 0.4751, p = 0.0022, respectively).

CONCLUSIONS:

The study indicated that CCR in the patients with SMID is a useful parameter that allows for the muscle mass to be estimated easily and accurately. This means that evaluating CCR could be used as a simple and important screening tool for PhA, FFM and muscle mass.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Músculo Esquelético / Creatinina / Cistatina C / Transtornos Motores / Deficiência Intelectual Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Músculo Esquelético / Creatinina / Cistatina C / Transtornos Motores / Deficiência Intelectual Idioma: En Ano de publicação: 2022 Tipo de documento: Article