Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing.
Exp Mol Med
; 53(11): 1647-1668, 2021 11.
Article
em En
| MEDLINE
| ID: mdl-34782737
ABSTRACT
A harmonized balance between positive and negative regulation of pattern recognition receptor (PRR)-initiated immune responses is required to achieve the most favorable outcome for the host. This balance is crucial because it must not only ensure activation of the first line of defense against viral infection but also prevent inappropriate immune activation, which results in autoimmune diseases. Recent studies have shown how signal transduction pathways initiated by PRRs are positively and negatively regulated by diverse modulators to maintain host immune homeostasis. However, viruses have developed strategies to subvert the host antiviral response and establish infection. Viruses have evolved numerous genes encoding immunomodulatory proteins that antagonize the host immune system. This review focuses on the current state of knowledge regarding key host factors that regulate innate immune signaling molecules upon viral infection and discusses evidence showing how specific viral proteins counteract antiviral responses via immunomodulatory strategies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Viroses
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Transdução de Sinais
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Genoma Viral
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Interações Hospedeiro-Patógeno
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Evasão da Resposta Imune
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Imunidade Inata
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article