Sensitive identification of neoantigens and cognate TCRs in human solid tumors.
Nat Biotechnol
; 40(5): 656-660, 2022 05.
Article
em En
| MEDLINE
| ID: mdl-34782741
ABSTRACT
The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-infiltrating lymphocytes. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen mediate regression of established tumors in patient-derived xenograft mice.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos T
/
Neoplasias
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article