Your browser doesn't support javascript.
loading
First clinical evaluation of breathing controlled four-dimensional computed tomography imaging.
Szkitsak, Juliane; Werner, René; Fernolendt, Susanne; Schwarz, Annette; Ott, Oliver J; Fietkau, Rainer; Hofmann, Christian; Bert, Christoph.
Afiliação
  • Szkitsak J; Department of Radiation Oncology, Universitätsklinikum Erlangen, 91054 Erlangen, Germany.
  • Werner R; Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
  • Fernolendt S; University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Schwarz A; Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
  • Ott OJ; Siemens Healthcare GmbH, 91301 Forchheim, Germany.
  • Fietkau R; Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
  • Hofmann C; Siemens Healthcare GmbH, 91301 Forchheim, Germany.
  • Bert C; Department of Radiation Oncology, Universitätsklinikum Erlangen, 91054 Erlangen, Germany.
Phys Imaging Radiat Oncol ; 20: 56-61, 2021 Oct.
Article em En | MEDLINE | ID: mdl-34786496
ABSTRACT
BACKGROUND AND

PURPOSE:

Four-dimensional computed tomography (4DCT) has become an essential part of radiotherapy planning but is often affected by artifacts. A new breathing controlled 4DCT (i4DCT) algorithm has been introduced. This study aims to present the first clinical data and to evaluate the achieved image quality, projection data coverage and beam-on time. MATERIAL &

METHODS:

The analysis included i4DCT data for 129 scans of patients with thoracic tumors. Projection data coverage and beam-on time were evaluated. Additionally, image quality was exemplarily discussed and rated by ten clinical experts with a 5-score-scale for 30 patients with large variations in their breathing pattern ('challenging subgroup'). Rated images were reconstructed amplitude- and phase-based.

RESULTS:

Expert scoring revealed that 78% (amplitude-based) and 63% (phase-based) of the challenging subgroup were artifact-free (rating ≥4). For the entire cohort, average beam-on time per couch position was 4.9 ± 1.6 s. For the challenging subgroup, time increased slightly but not significantly compared to the remaining patients (5.1 s vs. 4.9 s; p = 0.64). Median projection data coverage was 93% and 94% for inhalation and exhalation, respectively, for the entire cohort. The comparison for the subgroup and the remaining patients revealed a small but significant decrease of the median coverage values for the challenging cases (inhalation 90% vs. 94%, p = 0.02; exhalation 93% vs. 94%, p = 0.02).

CONCLUSIONS:

This first clinical evaluation of i4DCT shows very promising results in terms of image quality and projection data coverage. The results agree with and support the results of previous i4DCT phantom studies.
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article