Role of heme oxygenase-1 in the antidepressant-like effect of ursolic acid in the tail suspension test.
J Pharm Pharmacol
; 74(1): 13-21, 2022 Jan 05.
Article
em En
| MEDLINE
| ID: mdl-34791376
ABSTRACT
OBJECTIVES:
This study investigated the involvement of heme oxygenase-1 (HO-1) in the antidepressant-like effects of ursolic acid (UA), a plant-derived compound with neuroprotective and antidepressant-like properties.METHODS:
Mice received intracerebroventricular injections of zinc protoporphyrin IX (ZnPP) or cobalt protoporphyrin IX (CoPP) to inhibit or induce HO-1, respectively, together with effective (0.1 mg/kg, p.o.) or sub-effective (0.01 mg/kg, p.o.) doses of UA or fluoxetine (10 mg/kg, p.o.). Immobility time was assessed using the tail suspension test (TST) and the ambulatory behaviour with the open field test. HO-1 immunocontent was evaluated in mice hippocampus and prefrontal cortex. KEYFINDINGS:
ZnPP prevented the anti-immobility effects of UA and fluoxetine. Combined treatment with a sub-effective dose of CoPP and UA synergistically exerted antidepressant-like effects in the TST. Acute administration of UA or CoPP, but not fluoxetine, increased the HO-1 immunocontent in the hippocampus. None of the treatments altered the HO-1 immunocontent in the prefrontal cortex.CONCLUSIONS:
In conclusion, this work shows that increased hippocampal HO-1 content and activity mediate the antidepressant-like effect of UA in the TST.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Triterpenos
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Heme Oxigenase-1
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Hipocampo
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article