Prediction of cytochromes P450 3A and 2C19 modulation by both inflammation and drug interactions using physiologically based pharmacokinetics.

Lenoir, Camille; Niederer, Amine; Rollason, Victoria; Desmeules, Jules Alexandre; Daali, Youssef; Samer, Caroline Flora

Lenoir, Camille; Niederer, Amine; Rollason, Victoria; Desmeules, Jules Alexandre; Daali, Youssef; Samer, Caroline Flora.

Afiliação

Lenoir C; Division of Clinical Pharmacology and Toxicology, Department of Anaesthesiology, Pharmacology, Intensive Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland.
Niederer A; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
Rollason V; School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Desmeules JA; Division of Clinical Pharmacology and Toxicology, Department of Anaesthesiology, Pharmacology, Intensive Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland.
Daali Y; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
Samer CF; School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.

CPT Pharmacometrics Syst Pharmacol ; 11(1): 30-43, 2022 01.

Article em En | MEDLINE | ID: mdl-34791831

Assuntos

Esomeprazol/farmacologia; Inflamação/fisiopatologia; Interleucina-6/sangue; Midazolam/farmacocinética; Omeprazol/farmacologia; Citocromo P-450 CYP2C19/efeitos dos fármacos; Inibidores do Citocromo P-450 CYP2C19/farmacologia; Citocromo P-450 CYP3A/efeitos dos fármacos; Inibidores do Citocromo P-450 CYP3A/farmacologia; Regulação para Baixo; Interações Medicamentosas; Humanos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Midazolam / Omeprazol / Interleucina-6 / Esomeprazol / Inflamação Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google