SARS Cov-2 vaccination induces de novo donor-specific HLA antibodies in a renal transplant patient on waiting list: A case report.
HLA
; 99(1): 25-30, 2022 01.
Article
em En
| MEDLINE
| ID: mdl-34791833
ABSTRACT
The ability of COVID-19 vaccination to induce anti-HLA antibodies (Abs) formation in renal transplant candidates is not well studied. A 42-year-old man on a renal transplant waitlist, with no sensitization history, was tested for DSA before and after COVID-19 vaccination. Patient has consistently tested negative for COVID-19 virus. Eighteen days after receiving first dose of mRNA-based vaccine, flow cytometry crossmatch (FCXM) was strongly positive with de novo donor-specific Ab (dnDSA) against B57 and de novo non-DSA against B58. Before vaccination, preliminary FCXM was negative with no anti-HLA Abs. This event prompted the transplant team to cancel the surgery. COVID-19 vaccination could be associated with anti-HLA Abs formation in renal patients on waitlists that could affect future transplantability.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transplante de Rim
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Vacinas contra COVID-19
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COVID-19
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Isoanticorpos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article