Dearomatization-rearomatization strategy of tyrosine for peptide/protein modification through thiol-addition reactions.
Chem Commun (Camb)
; 57(96): 12968-12971, 2021 Dec 03.
Article
em En
| MEDLINE
| ID: mdl-34792042
ABSTRACT
We have developed a dearomatization-rearomatization strategy for the modification of peptides/proteins through a thiol-Michael addition to the electrophilic cyclohexadienone intermediate that is generated in situ via the oxidation of tyrosine. This strategy enriches the conjugation toolbox and has great potential for applications in medicinal chemistry and chemical biology.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Compostos de Sulfidrila
/
Tirosina
/
Proteínas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article