PD-L1 blockade exhibits anti-tumor effect on brain metastasis by activating CD8<sup>+</sup> T cells in hematogenous metastasis model with lymphocyte infusion.

Masuda, Chinami; Morinaga, Mamiko; Wakita, Daiko; Yorozu, Keigo; Kurasawa, Mitsue; Sugimoto, Masamichi; Kondoh, Osamu

PD-L1 blockade exhibits anti-tumor effect on brain metastasis by activating CD8⁺ T cells in hematogenous metastasis model with lymphocyte infusion.

Masuda, Chinami; Morinaga, Mamiko; Wakita, Daiko; Yorozu, Keigo; Kurasawa, Mitsue; Sugimoto, Masamichi; Kondoh, Osamu.

Afiliação

Masuda C; Product Research Department, Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd, 200 Kajiwara, Kamakura, 247-8530, Japan.
Morinaga M; Product Research Department, Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd, 200 Kajiwara, Kamakura, 247-8530, Japan.
Wakita D; Product Research Department, Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd, 200 Kajiwara, Kamakura, 247-8530, Japan.
Yorozu K; Product Research Department, Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd, 200 Kajiwara, Kamakura, 247-8530, Japan.
Kurasawa M; Product Research Department, Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd, 200 Kajiwara, Kamakura, 247-8530, Japan.
Sugimoto M; Product Research Department, Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd, 200 Kajiwara, Kamakura, 247-8530, Japan. sugimotomsm@chugai-pharm.co.jp.
Kondoh O; Product Research Department, Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd, 200 Kajiwara, Kamakura, 247-8530, Japan.

Clin Exp Metastasis ; 39(2): 335-344, 2022 04.

Article em En | MEDLINE | ID: mdl-34797455

Assuntos

Neoplasias Encefálicas; Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Animais; Antígeno B7-H1; Neoplasias Encefálicas/secundário; Linfócitos T CD8-Positivos; Carcinoma Pulmonar de Células não Pequenas/patologia; Linhagem Celular Tumoral; Humanos; Luciferases; Neoplasias Pulmonares/patologia; Linfócitos/metabolismo; Linfócitos/patologia; Camundongos; Camundongos SCID

Palavras-chave

Anti-PD-L1 antibody; CD8+ T cell; Hematogenous brain metastasis model; Luciferase reporter; Non-small-cell lung cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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