In vitro and in vivo studies reveal the beneficial effects of chlorogenic acid against ER stress mediated ER-phagy and associated apoptosis in the heart of diabetic rat.

Preetha Rani, M R; Salin Raj, P; Nair, Anupama; Ranjith, S; Rajankutty, K; Raghu, K G

Preetha Rani, M R; Salin Raj, P; Nair, Anupama; Ranjith, S; Rajankutty, K; Raghu, K G.

Afiliação

Preetha Rani MR; Biochemistry and Molecular Mechanism Laboratory, Agroprocessing and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram, Kerala, 695019, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Salin Raj P; Biochemistry and Molecular Mechanism Laboratory, Agroprocessing and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram, Kerala, 695019, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Nair A; Biochemistry and Molecular Mechanism Laboratory, Agroprocessing and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram, Kerala, 695019, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Ranjith S; Small Animal Research Facility, Jubilee Centre for Medical Research (JCMR), Jubilee Mission Medical College and Research Institute (JMMCRI), Thrissur, Kerala, 680005, India.
Rajankutty K; Small Animal Research Facility, Jubilee Centre for Medical Research (JCMR), Jubilee Mission Medical College and Research Institute (JMMCRI), Thrissur, Kerala, 680005, India.
Raghu KG; Biochemistry and Molecular Mechanism Laboratory, Agroprocessing and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram, Kerala, 695019, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. Electroni

Chem Biol Interact ; 351: 109755, 2022 Jan 05.

Article em En | MEDLINE | ID: mdl-34801538

Assuntos

Ácido Clorogênico/uso terapêutico; Diabetes Mellitus Experimental/tratamento farmacológico; Cardiomiopatias Diabéticas/tratamento farmacológico; Retículo Endoplasmático/efeitos dos fármacos; Coração/efeitos dos fármacos; Animais; Apoptose/efeitos dos fármacos; Autofagia/efeitos dos fármacos; Linhagem Celular; Diabetes Mellitus Experimental/patologia; Cardiomiopatias Diabéticas/patologia; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Hiperglicemia/tratamento farmacológico; Masculino; Miocárdio/patologia; Ratos Wistar; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Apoptosis; Chlorogenic acid; Diabetes; ER stress; ER-phagy; Heart

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Clorogênico / Diabetes Mellitus Experimental / Retículo Endoplasmático / Cardiomiopatias Diabéticas / Coração Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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