LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization.

ABSTRACT

ABBREVIATIONS A253-control A253 control for LAMP3 stable overexpression; A253- LAMP3 A253 LAPM3 stable overexpression; CASP1 caspase 1; CASP3 caspase 3; CHX cycloheximide; CTSB cathepsin B; CTSD cathepsin D; CQ chloroquine; DCs dendritic cells; ER endoplasmic reticulum; LGALS3 galectin 3; HCV hepatitis C virus; HSG-control HSG control for LAMP3 stable overexpression; HSG-LAMP3 HSG LAMP3 stable overexpression; HSP heat shock protein; HTLV-1 human T-lymphocyte leukemia virus-1; IXA ixazomib; LAMP lysosomal associated membrane protein; MHC major histocompatibility complex; mAb monoclonal antibody; OE overexpression; pepA pepstatin A; pAb polyclonal antibody; pSS primary Sjögren syndrome; qRT-PCR quantitative real- time reverse transcriptase polymerase chain reaction; SLE systemic lupus erythematosus; SS Sjögren syndrome; UPR unfolded protein response; V-ATPase vacuolar-type proton- translocating ATPase; Y-VAD Ac-YVAD-cmk; Z-DEVD; Z-DEVD-fmk; Z-VAD Z-VAD- fmk.