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Safety evaluation of high-risk myocardial micro-biopsy in a swine model.
Chireh, Arvin; Sandell, Mikael; Grankvist, Rikard; Lövljung, Victoria; Al-Saadi, Jonathan; Arnberg, Fabian; Lundberg, Johan; Settergren, Magnus; Holmin, Staffan.
Afiliação
  • Chireh A; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Sandell M; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Grankvist R; Division of Micro and Nanosystems, Royal Institute of Technology, Stockholm, Sweden.
  • Lövljung V; MedTechLabs, Solna, Sweden.
  • Al-Saadi J; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Arnberg F; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Lundberg J; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Settergren M; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Holmin S; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.
Heart Vessels ; 37(4): 697-704, 2022 Apr.
Article em En | MEDLINE | ID: mdl-34812914
ABSTRACT
The objective of the study was to investigate the safety profile of high-risk micro-endomyocardial biopsy (micro-EMB) compared to conventional EMB in a large animal model. Twenty pigs were subjected to a maximum of 30 consecutive biopsies, including sampling from the free ventricular wall, with either micro-EMB (n = 10) or conventional EMB (n = 10). There were no major complications in the micro-EMB group (0/10), compared to six major complications in the EMB group (6/10; p = 0.003). Survival analysis further highlighted these differences (p = 0.004). There were significantly higher volumes of pericardial effusion in the EMB group (p = 0.01). The study shows a safety advantage of micro-EMB compared to standard EMB in the experimental high-risk circumstances investigated in this animal study. These results indicate enhanced possibilities to collect samples from sensitive areas by using the micro-EMB technique instead of standard EMB.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Derrame Pericárdico / Miocárdio Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Derrame Pericárdico / Miocárdio Idioma: En Ano de publicação: 2022 Tipo de documento: Article