Mini-review: Local and downstream responses to the neuromuscular junction: Potential roles for integrins, connexins and ephrins in altering muscle characteristics and function.
Neurosci Lett
; 768: 136359, 2022 01 18.
Article
em En
| MEDLINE
| ID: mdl-34813913
ABSTRACT
Skeletal muscle develops in a manner directly related to its innervating motor neuron. The formation of the neuromuscular junction (NMJ) is a well-described process that is coordinated to allow for efficient communication between the central nervous system and muscle for muscle contraction and movement. Some of the major mediators of NMJ formation, like muscle-specific kinase, agrin and laminin, have been thoroughly described but there are other important proteins that have an integral role in muscle health that have also been associated with proper NMJ integrity and fiber health and function. This mini-review focuses on integrins, connexin hemichannels and ephrins and their relationship with the NMJin regulating muscle health.
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Base de dados:
MEDLINE
Assunto principal:
Integrinas
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Conexinas
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Músculo Esquelético
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Desenvolvimento Muscular
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Efrinas
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Junção Neuromuscular
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article