Antimetastatic defense by CD8+ T cells.
Trends Cancer
; 8(2): 145-157, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-34815204
ABSTRACT
Metastasis is an intricate process whereby tumor cells migrate from the primary tumor, survive in the circulation, seed distal organs, and proliferate to create metastatic foci. CD8+ T cells can detect and eliminate tumor cells. Research on CD8+ T cell-dependent antitumor immunity has classically focused on its role in the primary tumor. There is increasing evidence, however, that CD8+ T cells have unique antimetastatic functions in various steps of the metastatic cascade. Here, we review the mechanisms whereby CD8+ T cells control metastatic lesions. We discuss their role in each step of metastasis, metastatic dormancy, and metastatic clonal evolution as well as the consequent clinical repercussions.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD8-Positivos
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Neoplasias
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article