Reassessing the Pediatric Dosing Recommendations for Unfractionated Heparin Using Real-World Data: A Pharmacokinetic-Pharmacodynamic Modeling Approach.

Salem, Ahmed M; Niu, Tao; Li, Chao; Moffett, Brady S; Ivaturi, Vijay; Gopalakrishnan, Mathangi

Salem, Ahmed M; Niu, Tao; Li, Chao; Moffett, Brady S; Ivaturi, Vijay; Gopalakrishnan, Mathangi.

Afiliação

Salem AM; Center for Translational Medicine, Department of Pharmacy Practice, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.
Niu T; Modeling & Simulations, Vertex Pharmaceuticals, Boston, Massachusetts, USA.
Li C; Fosun Pharma, Princeton, New Jersey, USA.
Moffett BS; Department of Pharmacy, Texas Children's Hospital, Houston, Texas, USA.
Ivaturi V; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Gopalakrishnan M; Center for Translational Medicine, Department of Pharmacy Practice, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.

J Clin Pharmacol ; 62(6): 733-746, 2022 06.

Article em En | MEDLINE | ID: mdl-34816442

Assuntos

Heparina; Pediatria; Anticoagulantes/uso terapêutico; Criança; Inibidores do Fator Xa; Heparina/uso terapêutico; Humanos; Lactente; Tempo de Tromboplastina Parcial; Estudos Retrospectivos

Palavras-chave

UFH; aPTT; anti-factor Xa; pediatrics; population PK/PD

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pediatria / Heparina Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pediatria / Heparina Idioma: En Ano de publicação: 2022 Tipo de documento: Article