Treatment-related sequelae in Hodgkin's lymphoma after mediastinal irradiation.
Int J Hematol
; 115(3): 363-370, 2022 Mar.
Article
em En
| MEDLINE
| ID: mdl-34817791
ABSTRACT
BACKGROUND:
Many studies have investigated treatment-related sequelae in Hodgkin's lymphoma (HL) in high-prevalence areas, but very few have been conducted in low-prevalence areas, including Taiwan and Japan. MATERIALS ANDMETHODS:
We retrospectively reviewed 101 HL patients who had received mediastinal radiotherapy between January 1997 and April 2013.RESULTS:
Nine patients had cardiac events and nine patients developed second malignancies. Univariate analysis showed that bulkiness of disease was significantly associated with higher incidence of cardiac events (HR 7.70, 95% CI 1.60-38.00, p = 0.012). Disease stage and cumulative dose of radiotherapy were significantly correlated with incidence of radiation pneumonitis (HR 1.40, 95% CI 1.00-2.10, p = 0.043 and HR 1.10, 95% CI 1.00-1.20, p = 0.009, respectively). All cases of grade III-IV radiation pneumonitis happened in patients receiving a radiation dose higher than 35 Gy and developed within 4 months after radiotherapy.CONCLUSIONS:
Despite the similar incidence rates of treatment-related sequelae among HL survivors between areas with high and low prevalence of HL, cardiac events and second malignancies cannot be overlooked in HL survivors in low-prevalence areas.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Radioterapia
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Doença de Hodgkin
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Pneumonite por Radiação
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Cardiopatias
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article