Plakophilin3 loss leads to increased adenoma formation and rectal prolapse in APCmin mice.
Biochem Biophys Res Commun
; 586: 14-19, 2022 01 01.
Article
em En
| MEDLINE
| ID: mdl-34823217
ABSTRACT
Plakophilin3 (PKP3) loss leads to tumor progression and metastasis of colon cancer cells. The goal of this report was to determine if PKP3 loss led to increased disease progression in mice. We generated a colonocyte-specific knockout of PKP3 in APCmin mice, which led to increased adenoma formation, the formation of rectal prolapse, and a significant decrease in survival. The observed increase in rectal prolapse formation and decrease in survival correlated with an increase in the expression of Lipocalin2 (LCN2). Increased disease progression was observed even upon treatment with 5-fluorouracil (5FU). These results suggest that an increase in LCN2 expression might lead to therapy resistance and that LCN2 might serve as a potential therapeutic target in colorectal cancer.
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MEDLINE
Assunto principal:
Neoplasias Colorretais
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Adenoma
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Prolapso Retal
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Resistencia a Medicamentos Antineoplásicos
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Placofilinas
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Lipocalina-2
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article