Amyloid-Beta Peptides and Activated Astroglia Impairs Proliferation of Nerve Growth Factor Releasing Cells In Vitro: Implication for Encapsulated Cell Biodelivery-Mediated AD Therapy.

Mitra, Sumonto; Turchetto, Silvia; Van Os, Winant; Wahlberg, Lars U; Linderoth, Bengt; Behbahani, Homira; Eriksdotter, Maria

Mitra, Sumonto; Turchetto, Silvia; Van Os, Winant; Wahlberg, Lars U; Linderoth, Bengt; Behbahani, Homira; Eriksdotter, Maria.

Afiliação

Mitra S; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, 141 52 Stockholm, Sweden.
Turchetto S; Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, 171 64 Stockholm, Sweden.
Van Os W; GIGA-Stem Cells and GIGA-Neurosciences, Interdisciplinary Cluster for Applied Geno-Proteomics (GIGA-R), University of Liège, 4000 Liège, Belgium.
Wahlberg LU; Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, 171 64 Stockholm, Sweden.
Linderoth B; Wiskunde en Natuurwetenschappen, LIC/Chemical Biology, Leiden Institute of Chemistry, 2300 RA Leiden, The Netherlands.
Behbahani H; Gloriana Therapeutics, Inc., Warren, Rhode Island, RI 02885, USA.
Eriksdotter M; Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.

Cells ; 10(11)2021 10 21.

Article em En | MEDLINE | ID: mdl-34831056

Assuntos

Doença de Alzheimer/patologia; Peptídeos beta-Amiloides/metabolismo; Astrócitos/metabolismo; Células Imobilizadas/citologia; Fator de Crescimento Neural/metabolismo; Doença de Alzheimer/líquido cefalorraquidiano; Linhagem Celular; Proliferação de Células; Disfunção Cognitiva/líquido cefalorraquidiano; Meios de Cultivo Condicionados/farmacologia; Humanos; Doença por Corpos de Lewy/líquido cefalorraquidiano; Peptídeos/metabolismo; Estresse Fisiológico

Palavras-chave

Alzheimer's disease (AD); amyloid beta (Aß); astrocytes; drug delivery strategy optimization; encapsulated cell biodelivery (ECB); inflammation; nerve growth factor (NGF)

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Astrócitos / Peptídeos beta-Amiloides / Células Imobilizadas / Fator de Crescimento Neural / Doença de Alzheimer Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google