Your browser doesn't support javascript.
loading
A Plausible Proposition of CCL20-Related Mechanism in Fusobacterium nucleatum-Associated Oral Carcinogenesis.
Mandal, Devi Prasad; Mohanty, Neeta; Behera, Paresh Kumar; Gopinath, Divya; Panda, Sasmita; Al-Kheraif, Abdulaziz A; Divakar, Darshan Devang; Anil, Sukumaran; Panda, Swagatika.
Afiliação
  • Mandal DP; Institute of Dental Sciences, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar 751030, Odisha, India.
  • Mohanty N; Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar 751030, Odisha, India.
  • Behera PK; Head and Neck Oncology, Acharya Harihar Regional Cancer Centre, Cuttack 753007, Odisha, India.
  • Gopinath D; Clinical Oral Health Sciences Division, School of Dentistry, International Medical University, Kuala Lumpur 57000, Malaysia.
  • Panda S; Department of Pathology, Acharya Harihar Regional Cancer Centre, Cuttack 753007, Odisha, India.
  • Al-Kheraif AA; Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.
  • Divakar DD; Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.
  • Anil S; Department of Dentistry, Oral Health Institute, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar.
  • Panda S; College of Dental Medicine, Qatar University, Doha P.O. Box 2713, Qatar.
Life (Basel) ; 11(11)2021 Nov 10.
Article em En | MEDLINE | ID: mdl-34833094
OBJECTIVE: The objective of this prospective observational case-control study is to evaluate the prevalence of Fusobacterium nucleatum in the tissues of oral squamous cell carcinoma (OSCC). Reconnoitering the CCL20-related mechanism of carcinogenesis in Fusobacterium nucleatum-positive OSCC is another objective. METHODOLOGY: Tissues from 50 OSCC patients and 30 healthy oral tissues were collected. The prevalence of Fusobacterium nucleatum was evaluated in both tumour and healthy tissue by polymerase chain reaction. The immunohistochemistry of OSCC tissues was conducted to evaluate the difference in the expression of CCL20 between Fusobacterium nucleatum-positive and -negative OSCC tissues. RESULTS: Fusobacterium nucleatum was significantly (p < 0.001) prevalent in OSCC tissues (74%), compared to healthy tissues (26%). No association of Fusobacterium nucleatum or CCL20 immuno-expression with any clinical or histopathological features of OSCC was observed. While the intensity of CCL20 immuno-expression did not differ (p = 0.053), the CCL20-positive cell population was significantly different (p = 0.034) between Fusobacterium nucleatum-positive and -negative OSCC. CONCLUSION: Fusobacterium nucleatum is possibly prevalent in oral cancer tissues in the Indian population. By using immunohistochemistry, this is the first study to propose that the carcinogenesis in Fusobacterium nucleatum-positive OSCC may be CCL20-related. The findings enrich the knowledge of mechanisms involved in Fusobacterium nucleatum-mediated oral carcinogenesis.
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article