Peritoneal Administration of a Subunit Vaccine Encapsulated in a Nanodelivery System Not Only Augments Systemic Responses against SARS-CoV-2 but Also Stimulates Responses in the Respiratory Tract.

Jearanaiwitayakul, Tuksin; Apichirapokey, Suttikarn; Chawengkirttikul, Runglawan; Limthongkul, Jitra; Seesen, Mathurin; Jakaew, Phissinee; Trisiriwanich, Sakalin; Sapsutthipas, Sompong; Sunintaboon, Panya; Ubol, Sukathida

Jearanaiwitayakul, Tuksin; Apichirapokey, Suttikarn; Chawengkirttikul, Runglawan; Limthongkul, Jitra; Seesen, Mathurin; Jakaew, Phissinee; Trisiriwanich, Sakalin; Sapsutthipas, Sompong; Sunintaboon, Panya; Ubol, Sukathida.

Afiliação

Jearanaiwitayakul T; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Apichirapokey S; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Chawengkirttikul R; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Limthongkul J; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Seesen M; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Jakaew P; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Trisiriwanich S; Institute of Biological Products, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand.
Sapsutthipas S; Institute of Biological Products, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand.
Sunintaboon P; Department of Chemistry, Faculty of Science, Mahidol University, Salaya, Nakornpatom 73170, Thailand.
Ubol S; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Viruses ; 13(11)2021 11 02.

Article em En | MEDLINE | ID: mdl-34835008

Assuntos

Vacinas contra COVID-19/imunologia; COVID-19/imunologia; COVID-19/virologia; Imunidade; SARS-CoV-2/imunologia; Glicoproteína da Espícula de Coronavírus/imunologia; Vacinas de Subunidades Antigênicas/imunologia; Animais; Anticorpos Neutralizantes/imunologia; Anticorpos Antivirais/imunologia; Formação de Anticorpos; COVID-19/prevenção & controle; Feminino; Humanos; Imunidade nas Mucosas; Imunização/métodos; Imunogenicidade da Vacina; Camundongos; Camundongos Endogâmicos BALB C; Sistemas de Liberação de Fármacos por Nanopartículas/uso terapêutico; Nanopartículas/uso terapêutico; Proteínas Recombinantes/imunologia; Sistema Respiratório/imunologia; Linfócitos T/imunologia; Vacinação; Vacinas de Subunidades Antigênicas/administração & dosagem

Palavras-chave

COVID-19 vaccine; SARS-CoV-2 spike glycoprotein; adjuvant delivery particles; mucosal immunity; peritoneal immunization

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas de Subunidades Antigênicas / Glicoproteína da Espícula de Coronavírus / Vacinas contra COVID-19 / SARS-CoV-2 / COVID-19 / Imunidade Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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