Intensity-modulated proton radiation therapy as a radical treatment modality for nasopharyngeal carcinoma in China: Cost-effectiveness analysis.
Head Neck
; 44(2): 431-442, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-34837286
ABSTRACT
BACKGROUND:
Compared to conventional intensity-modulated photon radiation therapy (IMRT), intensity-modulated proton radiation therapy (IMPT) has potential to reduce irradiation-induced late toxicities while maintaining excellent tumor control in patients with nasopharyngeal carcinoma (NPC). However, the relevant cost-effectiveness remains controversial.METHODS:
A Markov decision tree analysis was performed under the assumption that IMPT offered normal tissue complication probability reduction (NTCP reduction) in long-term dysphagia, xerostomia, and hearing loss, compared to IMRT. Base-case evaluation was performed on T2N2M0 NPC of median age (43 years old). A Chinese societal willingness-to-pay threshold (33558 US dollars [$])/quality-adjusted life-year [QALY]) was adopted.RESULTS:
For patients at median age and having NTCP reduction of 10%, 20%, 30%, 40%, 50%, and 60%, their incremental cost-effectiveness ratios were $102684.0/QALY, $43161.2/QALY, $24134.7/QALY, $13991.6/QALY, $8259.8/QALY, and $4436.1/QALY, respectively; IMPT should provide an NTCP reduction of ≥24% to be considered cost-effective.CONCLUSIONS:
IMPT has potential to be cost-effective for average Chinese NPC patients and should be validated clinically.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Nasofaríngeas
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Radioterapia de Intensidade Modulada
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Terapia com Prótons
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article