Identification of Vulnerable Interneuron Subtypes in 15q13.3 Microdeletion Syndrome Using Single-Cell Transcriptomics.

Malwade, Susmita; Gasthaus, Janina; Bellardita, Carmelo; Andelic, Matej; Moric, Borna; Korshunova, Irina; Kiehn, Ole; Vasistha, Navneet A; Khodosevich, Konstantin

Malwade, Susmita; Gasthaus, Janina; Bellardita, Carmelo; Andelic, Matej; Moric, Borna; Korshunova, Irina; Kiehn, Ole; Vasistha, Navneet A; Khodosevich, Konstantin.

Afiliação

Malwade S; Biotech Research and Innovation Center (BRIC), Copenhagen Biocenter, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Gasthaus J; Biotech Research and Innovation Center (BRIC), Copenhagen Biocenter, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Bellardita C; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Andelic M; Biotech Research and Innovation Center (BRIC), Copenhagen Biocenter, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Moric B; Biotech Research and Innovation Center (BRIC), Copenhagen Biocenter, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Korshunova I; Biotech Research and Innovation Center (BRIC), Copenhagen Biocenter, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kiehn O; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Vasistha NA; Biotech Research and Innovation Center (BRIC), Copenhagen Biocenter, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: navneet.vasistha@bric.ku.dk.
Khodosevich K; Biotech Research and Innovation Center (BRIC), Copenhagen Biocenter, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: konstantin.khodosevich@bric.ku.dk.

Biol Psychiatry ; 91(8): 727-739, 2022 04 15.

Article em En | MEDLINE | ID: mdl-34838304

Assuntos

Transtornos Cromossômicos; Transcriptoma; Animais; Deleção Cromossômica; Transtornos Cromossômicos/genética; Cromossomos Humanos Par 15; Deficiência Intelectual; Interneurônios/metabolismo; Camundongos; Convulsões

Palavras-chave

CNV; Epilepsy; Interneurons; Klf13; Schizophrenia; scRNA-seq

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Cromossômicos / Transcriptoma Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Cromossômicos / Transcriptoma Idioma: En Ano de publicação: 2022 Tipo de documento: Article