Biochemical genesis of enzymatic and non-enzymatic post-translational modifications.
Mol Aspects Med
; 86: 101053, 2022 08.
Article
em En
| MEDLINE
| ID: mdl-34838336
ABSTRACT
Post-translational modifications (PTMs) alter protein structure, function, and localization and play a pivotal role in physiological and pathophysiological conditions. Many PTMs arise from endogenous metabolic intermediates and serve as sensors for metabolic feedback to maintain cell growth and homeostasis. A key feature to PTMs is their biochemical genesis, which can result from either non-enzymatic adduction (nPTMs) or through enzyme-catalyzed reactions (ePTMs). The abundance and site-specificity of PTMs are determined by dedicated classes of enzymes that add (writers) or remove (erasers) the chemical addition. In this review we will highlight the biochemical genesis and regulation of a few of the 700+ PTMs that have been identified.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Processamento de Proteína Pós-Traducional
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article