Your browser doesn't support javascript.
loading
Serum urate as a proposed surrogate outcome measure in gout trials: From the OMERACT working group.
Morillon, Melanie Birger; Christensen, Robin; Singh, Jasvinder A; Dalbeth, Nicola; Saag, Kenneth; Taylor, William J; Neogi, Tuhina; Kennedy, Martin A; Pedersen, Birthe M; McCarthy, Geraldine M; Shea, Beverley; Diaz-Torne, Cesar; Tedeschi, Sara K; Grainger, Rebecca; Abhishek, Abhishek; Gaffo, Angelo; Nielsen, Sabrina Mai; Noerup, Alexander; Simon, Lee S; Lassere, Marissa; Tugwell, Peter; Stamp, Lisa K; Gout Working Group, For The Omeract.
Afiliação
  • Morillon MB; Section for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark; Department of Medicine
  • Christensen R; Section for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark.
  • Singh JA; Birmingham Veterans Affairs (VA) Medical Center, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Dalbeth N; University of Auckland, New Zealand.
  • Saag K; Birmingham Veterans Affairs (VA) Medical Center, University of Alabama, Birmingham, AL, USA.
  • Taylor WJ; University of Otago, Wellington, New Zealand.
  • Neogi T; Rheumatology, Medicine, Boston Medical Center.
  • Kennedy MA; OMERACT Patient Research Partner, Christchurch, New Zealand.
  • Pedersen BM; OMERACT Patient Research Partner, Aarhus, Denmark.
  • McCarthy GM; Division of Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland.
  • Shea B; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • Diaz-Torne C; Rheumatology Department. Hospital de la Santa Creu i Sant Pau. Universitat Autònoma de Barcelona. Barcelona.
  • Tedeschi SK; Brigham and Women's Hospital, Division of Rheumatology, Inflammation and Immunity, Boston, USA.
  • Grainger R; Rehabilitation Teaching and Research Unit, Department of Medicine, University of Otago Wellington, Wellington, New Zealand.
  • Abhishek A; Academic Rheumatology, University of Nottingham, Nottingham, UK.
  • Gaffo A; Birmingham Veterans Affairs (VA) Medical Center, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Nielsen SM; Section for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark.
  • Noerup A; Section for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark.
  • Simon LS; SDG LLC, Cambridge, MA, USA.
  • Lassere M; Department of Rheumatology, St George Hospital, University of NSW, Sydney, Australia.
  • Tugwell P; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Stamp LK; Department of Medicine, University of Otago, Christchurch, New Zealand. Electronic address: lisa.stamp@chdb.health.nz.
  • Gout Working Group FTO; Section for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Semin Arthritis Rheum ; 51(6): 1378-1385, 2021 12.
Article em En | MEDLINE | ID: mdl-34839932
Serum urate (SU) is the most common primary efficacy outcome in trials of urate-lowering therapies for gout. Despite this, it is not formally considered a validated surrogate outcome. In this paper we will outline the definitions of biomarkers and surrogate outcome measures, respectively as well as the available frameworks and challenges in the assessment of the validity of serum urate as a surrogate in gout (i.e. a reasonable replacement for gout symptoms).
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Úrico / Gota Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Úrico / Gota Idioma: En Ano de publicação: 2021 Tipo de documento: Article