Age-related Activation of Cyclic GMP-AMP synthase-Stimulator of Interferon Genes Signaling in the Auditory System is Associated with Presbycusis in C57BL/6J Male Mice.

Liu, Jinlan; Chen, Huiying; Lin, Xiaoyu; Yi, Jianqi; Ye, Wanli; Wei, Fangyu; Zhu, Xiaoting; Huang, Jialin; Su, Jiping

Liu, Jinlan; Chen, Huiying; Lin, Xiaoyu; Yi, Jianqi; Ye, Wanli; Wei, Fangyu; Zhu, Xiaoting; Huang, Jialin; Su, Jiping.

Afiliação

Liu J; Department of Otolaryngology-Head & Neck Surgery, First Afliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China.
Chen H; Department of Otolaryngology-Head & Neck Surgery, First Afliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China.
Lin X; Department of Otolaryngology-Head & Neck Surgery, First Afliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China.
Yi J; Department of Otolaryngology-Head & Neck Surgery, First Afliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China.
Ye W; Department of Otolaryngology-Head & Neck Surgery, First Afliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China.
Wei F; Department of Otolaryngology-Head & Neck Surgery, First Afliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China.
Zhu X; Department of Otolaryngology-Head & Neck Surgery, First Afliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China.
Huang J; Department of Otolaryngology-Head & Neck Surgery, First Afliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China.
Su J; Department of Otolaryngology-Head & Neck Surgery, First Afliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China. Electronic address: ymsu2@126.com.

Neuroscience ; 481: 73-84, 2022 01 15.

Article em En | MEDLINE | ID: mdl-34848262

Assuntos

Interferons; Presbiacusia; Animais; Masculino; Proteínas de Membrana/genética; Proteínas de Membrana/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Nucleotídeos Cíclicos; Nucleotidiltransferases/genética; Nucleotidiltransferases/metabolismo

Palavras-chave

Aging; age-related hearing loss; cGASSTING pathway; inflammation; mitochondrial DNA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Presbiacusia / Interferons Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Presbiacusia / Interferons Idioma: En Ano de publicação: 2022 Tipo de documento: Article