Near-Infrared Emissive Lanthanide Metal-Organic Frameworks for Targeted Biological Imaging and pH-Controlled Chemotherapy.
ACS Appl Mater Interfaces
; 13(49): 59164-59173, 2021 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-34851097
ABSTRACT
Near-infrared window II (NIR-II, 1000-1700 nm) imaging displays the advantages in deep-tissue high-contrast imaging in vivo on the strength of the high temporal-spatial resolution and deeper penetration. However, the clinical utility of NIR-II imaging agents is limited by their single function. Herein, for the first time, we report the design of a multifunctional drug delivery system (DDS) assembly, CQ/Nd-MOF@HA nanohybrids, with NIR-II fluorescence (1067 nm), large Stokes shifts, and ultrahigh quantum yield, which combined targeted NIR-II luminescence bioimaging and pH-controlled drug delivery. The nanoscale metal-organic framework (MOF) as a highly promising multifunctional DDS for targeted NIR-II bioimaging and chemotherapy in vitro and in vivo lays the foundation of the MOF-based DDS for further clinical diagnosis and treatment.
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MEDLINE
Assunto principal:
Neoplasias Ovarianas
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Imagem Óptica
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Estruturas Metalorgânicas
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Ácido Hialurônico
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Neodímio
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Antineoplásicos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article