Association between hyperlipidemia and calcium oxalate lower urinary tract uroliths in dogs.
J Vet Intern Med
; 36(1): 146-155, 2022 Jan.
Article
em En
| MEDLINE
| ID: mdl-34854133
ABSTRACT
BACKGROUND:
Metabolic syndrome is associated with formation of calcium oxalate (CaOx) uroliths in humans.OBJECTIVES:
To investigate the association between obesity and hyperlipidemia with CaOx lower urinary tract uroliths in client-owned dogs. ANIMALS Dogs with (n = 55, U [uroliths]-dogs) and without (n = 39, UF [uroliths-free]-dogs) CaOx lower urinary tract uroliths.METHODS:
Case-control study. U-dogs were retrospectively enrolled and compared to UF-dogs. Body condition score (BCS; 1-9 scoring scale), serum triglyceride (TG) and total cholesterol (CH) concentrations and glycemia (after >12-hour food withholding) were recorded in both groups.RESULTS:
On univariate logistic regression, when excluding Miniature Schnauzers, odds of having uroliths increased by a factor of 3.32 (95% CI 1.38-11.12) for each mmol/L of TG (P = .027), of 39 (95% CI 9.27-293.22) for each mmol/L of glycemia (P < .0001), and of 2.43 (95% CI 1.45-4.45) per unit of BCS (P = .002). In multivariable models, the effect of TG was retained when all breeds were included for analysis and odds of having uroliths increased by a factor of 4.34 per mmol/L of TG (95% CI 1.45-19.99; P = .02). CONCLUSIONS AND CLINICAL IMPORTANCE Serum lipid screening in dogs diagnosed with CaOx uroliths might be recommended to improve their medical staging and management.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Sistema Urinário
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Doenças do Cão
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Urolitíase
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Hiperlipidemias
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article