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Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity.
Ma, Chunlong; Xia, Zilei; Sacco, Michael Dominic; Hu, Yanmei; Townsend, Julia Alma; Meng, Xiangzhi; Choza, Juliana; Tan, Haozhou; Jang, Janice; Gongora, Maura V; Zhang, Xiujun; Zhang, Fushun; Xiang, Yan; Marty, Michael Thomas; Chen, Yu; Wang, Jun.
Afiliação
  • Ma C; Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States.
  • Xia Z; Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States.
  • Sacco MD; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States.
  • Hu Y; Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States.
  • Townsend JA; Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona 85721, United States.
  • Meng X; Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
  • Choza J; Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States.
  • Tan H; Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States.
  • Jang J; Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States.
  • Gongora MV; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States.
  • Zhang X; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States.
  • Zhang F; Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
  • Xiang Y; Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
  • Marty MT; Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona 85721, United States.
  • Chen Y; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States.
  • Wang J; Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States.
J Am Chem Soc ; 143(49): 20697-20709, 2021 12 15.
Article em En | MEDLINE | ID: mdl-34860011
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Inibidores de Proteases / Proteases 3C de Coronavírus / SARS-CoV-2 / Acetamidas Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Inibidores de Proteases / Proteases 3C de Coronavírus / SARS-CoV-2 / Acetamidas Idioma: En Ano de publicação: 2021 Tipo de documento: Article