The ASCEND-ND trial: study design and participant characteristics.
Nephrol Dial Transplant
; 37(11): 2157-2170, 2022 10 19.
Article
em En
| MEDLINE
| ID: mdl-34865143
ABSTRACT
BACKGROUND:
Anaemia is common in chronic kidney disease (CKD) and assessment of the risks and benefits of new therapies is important.METHODS:
The Anaemia Study in CKD Erythropoiesis via a Novel prolyl hydroxylase inhibitor Daprodustat-Non-Dialysis (ASCEND-ND) trial includes adult patients with CKD Stages 3-5, not using erythropoiesis-stimulating agents (ESAs) with screening haemoglobin (Hb) 8-10 g/dL or receiving ESAs with screening Hb of 8-12 g/dL. Participants were randomized to daprodustat or darbepoetin alfa (11) in an open-label trial (steering committee- and sponsor-blinded), with blinded endpoint assessment. The co-primary endpoints are mean change in Hb between baseline and evaluation period (average over Weeks 28-52) and time to first adjudicated major adverse cardiovascular (CV) event. Baseline characteristics were compared with those of participants in similar anaemia trials.RESULTS:
Overall, 3872 patients were randomized from 39 countries (median age 67 years, 56% female, 56% White, 27% Asian and 10% Black). The median baseline Hb was 9.9 g/dL, blood pressure was 135/74 mmHg and estimated glomerular filtration rate was 18 mL/min/1.73 m2. Among randomized patients, 53% were ESA non-users, 57% had diabetes and 37% had a history of CV disease. At baseline, 61% of participants were using renin-angiotensin system blockers, 55% were taking statins and 49% were taking oral iron. Baseline demographics were similar to those in other large non-dialysis anaemia trials.CONCLUSION:
ASCEND-ND will define the efficacy and safety of daprodustat compared with darbepoetin alfa in the treatment of patients with anaemia associated with CKD not on dialysis.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Eritropoetina
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Inibidores de Hidroximetilglutaril-CoA Redutases
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Insuficiência Renal Crônica
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Inibidores de Prolil-Hidrolase
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Hematínicos
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Anemia
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article