Cyclodextrin metal-organic framework as vaccine adjuvants enhances immune responses.
Drug Deliv
; 28(1): 2594-2602, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-34866536
ABSTRACT
It is urgently needed to develop novel adjuvants for improving the safety and efficacy of vaccines. Metal-organic frameworks (MOFs), with high surface area, play an important role in drug delivery. With perfect biocompatibility and green preparation process, the γ-cyclodextrin metal-organic framework (γ-CD-MOF) fabricated with cyclodextrin and potassium suitable for antigen delivery. In this study, we modified γ-CD-MOF with span-85 to fabricate the SP-γ-CD-MOF as animal vaccine adjuvants. The ovalbumin (OVA) as the model antigen was encapsulated into particles to investigate the immune response. SP-γ-CD-MOF displayed excellent biocompatibility in vitro and in vivo. After immunization, SP-γ-CD-MOF loaded with OVA could induce high antigen-specific IgG titers and cytokine secretion. Meanwhile, SP-γ-CD-MOF also significantly improved the proliferation of spleen cells and activated and matured the bone marrow dendritic cells (BMDCs). The study showed the potential of SP-γ-CD-MOF in vaccine adjuvants and provided a novel idea for the development of vaccine adjuvants.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ovalbumina
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Gama-Ciclodextrinas
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Estruturas Metalorgânicas
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Adjuvantes de Vacinas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article