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Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults.
Wang, Yang; Du, Ming-Fei; Yao, Shi; Zou, Ting; Zhang, Xiao-Yu; Hu, Gui-Lin; Chu, Chao; Liao, Yue-Yuan; Chen, Chen; Wang, Dan; Ma, Qiong; Wang, Ke-Ke; Sun, Yue; Niu, Ze-Jiaxin; Yan, Rui-Chen; Yan, Yu; Zhou, Hao-Wei; Jia, Hao; Gao, Wei-Hua; Li, Hao; Li, Chun-Hua; Chen, Fang-Yao; Gao, Ke; Zhang, Jie; Safirstein, Robert; Wang, Feng; Yang, Tie-Lin; Mu, Jian-Jun.
Afiliação
  • Wang Y; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Du MF; Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
  • Yao S; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Zou T; Key Laboratory of Biomedical Information Engineering of Ministry of Education, Biomedical Informatics & Genomics Center, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.
  • Zhang XY; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Hu GL; Department of Cardiology, Northwest Women's and Children's Hospital of Xi'an Jiaotong University Health Science Center, Xi'an, China.
  • Chu C; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Liao YY; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Chen C; Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
  • Wang D; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Ma Q; Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
  • Wang KK; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Sun Y; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Niu ZJ; Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
  • Yan RC; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Yan Y; Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
  • Zhou HW; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Jia H; Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
  • Gao WH; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Li H; Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
  • Li CH; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Chen FY; Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
  • Gao K; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Zhang J; Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
  • Safirstein R; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Wang F; Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
  • Yang TL; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Mu JJ; Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Front Cardiovasc Med ; 8: 710023, 2021.
Article em En | MEDLINE | ID: mdl-34869624
Background: Uromodulin, also named Tamm Horsfall protein, has been associated with renal function and regulation of sodium homeostasis. We aimed to examine the associations of serum uromodulin levels and its genetic variants with longitudinal blood pressure (BP) changes and hypertension incidence/risk. Methods: A total of 514 participants from the original Baoji Salt-Sensitive Study cohort were genotyped to examine the associations of genetic variations in uromodulin gene with the longitudinal BP changes and the incidence of hypertension over 8 years of follow-up. In addition, 2,210 subjects from the cohort of Hanzhong Adolescent Hypertension Study were used to investigate the relationships between serum uromodulin levels and the risk of hypertension. Results: SNPs rs12917707 and rs12708631 in the uromodulin gene were significantly associated with the longitudinal BP changes over 8 years of follow-up. SNP rs12708631 was significantly associated with the incidence of hypertension over 8 years. In addition, gene-based analyses supported the associations of uromodulin gene with the longitudinal BP changes and hypertension incidence in Baoji Salt-Sensitive Study cohort. Furthermore, serum uromodulin levels in the hypertensive subjects were lower than in the normotensive subjects (25.5 ± 1.1 vs. 34.7 ± 0.7 ng/mL). Serum uromodulin levels decreased gradually as BP levels increased (34.6, 33.2, 27.8, and 25.0 ng/mL for subjects with normotension, high-normal, grade 1 hypertension, and grade 2 hypertension, respectively). Serum uromodulin was significantly associated with the lower risk of hypertension [0.978 (0.972-0.984)] in Hanzhong Adolescent Hypertension Study cohort. Conclusion: This study shows that uromodulin is associated with blood pressure progression and development of hypertension.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article