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Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence.
Katsarou, Afroditi; Sjöstrand, Maria; Naik, Jyoti; Mansilla-Soto, Jorge; Kefala, Dionysia; Kladis, Georgios; Nianias, Alexandros; Ruiter, Ruud; Poels, Renée; Sarkar, Irene; Patankar, Yash R; Merino, Elena; Reijmers, Rogier M; Frerichs, Kristine A; Yuan, Huipin; de Bruijn, Joost; Stroopinsky, Dina; Avigan, David; van de Donk, Niels W C J; Zweegman, Sonja; Mutis, Tuna; Sadelain, Michel; Groen, Richard W J; Themeli, Maria.
Afiliação
  • Katsarou A; Department of Hematology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, Netherlands.
  • Sjöstrand M; Center for Cell Engineering, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Naik J; Department of Hematology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, Netherlands.
  • Mansilla-Soto J; Center for Cell Engineering, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Kefala D; Department of Hematology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, Netherlands.
  • Kladis G; Department of Hematology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, Netherlands.
  • Nianias A; Department of Hematology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, Netherlands.
  • Ruiter R; Department of Hematology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, Netherlands.
  • Poels R; Department of Hematology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, Netherlands.
  • Sarkar I; LUMICKS, Pilotenstraat 41, 1059 CH Amsterdam, Netherlands.
  • Patankar YR; LUMICKS, Pilotenstraat 41, 1059 CH Amsterdam, Netherlands.
  • Merino E; LUMICKS, Pilotenstraat 41, 1059 CH Amsterdam, Netherlands.
  • Reijmers RM; LUMICKS, Pilotenstraat 41, 1059 CH Amsterdam, Netherlands.
  • Frerichs KA; Department of Hematology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, Netherlands.
  • Yuan H; Kuros Biosciences BV, 3723 MB Bilthoven, Netherlands.
  • de Bruijn J; Kuros Biosciences BV, 3723 MB Bilthoven, Netherlands.
  • Stroopinsky D; School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, UK.
  • Avigan D; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • van de Donk NWCJ; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Zweegman S; Department of Hematology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, Netherlands.
  • Mutis T; Department of Hematology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, Netherlands.
  • Sadelain M; Department of Hematology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, Netherlands.
  • Groen RWJ; Center for Cell Engineering, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Themeli M; Department of Hematology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, Netherlands.
Sci Transl Med ; 13(623): eabh1962, 2021 12 08.
Article em En | MEDLINE | ID: mdl-34878825
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Antígenos Quiméricos / Mieloma Múltiplo Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Antígenos Quiméricos / Mieloma Múltiplo Idioma: En Ano de publicação: 2021 Tipo de documento: Article