BP-M345, a New Diarylpentanoid with Promising Antimitotic Activity.
Molecules
; 26(23)2021 Nov 25.
Article
em En
| MEDLINE
| ID: mdl-34885726
ABSTRACT
Previously, we reported the in vitro growth inhibitory effect of diarylpentanoid BP-M345 on human cancer cells. Nevertheless, at that time, the cellular mechanism through which BP-M345 exerts its growth inhibitory effect remained to be explored. In the present work, we report its mechanism of action on cancer cells. The compound exhibits a potent tumor growth inhibitory activity with high selectivity index. Mechanistically, it induces perturbation of the spindles through microtubule instability. As a consequence, treated cells exhibit irreversible defects in chromosome congression during mitosis, which induce a prolonged spindle assembly checkpoint-dependent mitotic arrest, followed by massive apoptosis, as revealed by live cell imaging. Collectively, the results indicate that the diarylpentanoid BP-M345 exerts its antiproliferative activity by inhibiting mitosis through microtubule perturbation and causing cancer cell death, thereby highlighting its potential as antitumor agent.
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Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
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Mitose
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Neoplasias
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Antineoplásicos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article