Your browser doesn't support javascript.
loading
Vitamin D status is heritable and under environment-dependent selection in the wild.
Sparks, Alexandra M; Johnston, Susan E; Handel, Ian; Pilkington, Jill G; Berry, Jacqueline; Pemberton, Josephine M; Nussey, Daniel H; Mellanby, Richard J.
Afiliação
  • Sparks AM; Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
  • Johnston SE; Faculty of Biological Sciences, School of Biology, University of Leeds, Leeds, UK.
  • Handel I; Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
  • Pilkington JG; Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Roslin, UK.
  • Berry J; Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
  • Pemberton JM; Specialist Assay Laboratory (Vitamin D), Clinical Biochemistry, Manchester Royal Infirmary, Manchester, UK.
  • Nussey DH; Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
  • Mellanby RJ; Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Mol Ecol ; 31(18): 4607-4621, 2022 09.
Article em En | MEDLINE | ID: mdl-34888965
Vitamin D has a well-established role in skeletal health and is increasingly linked to chronic disease and mortality in humans and companion animals. Despite the clear significance of vitamin D for health and obvious implications for fitness under natural conditions, no longitudinal study has tested whether the circulating concentration of vitamin D is under natural selection in the wild. Here, we show that concentrations of dietary-derived vitamin D2 and endogenously produced vitamin D3  metabolites are heritable and largely polygenic in a wild population of Soay sheep (Ovis aries). Vitamin D2  status was positively associated with female adult survival, and vitamin D3  status predicted female fecundity in particular, good environment years when sheep density and competition for resources was low. Our study provides evidence that vitamin D status has the potential to respond to selection, and also provides new insights into how vitamin D metabolism is associated with fitness in the wild.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vitamina D / Ergocalciferóis Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vitamina D / Ergocalciferóis Idioma: En Ano de publicação: 2022 Tipo de documento: Article