Anesthetic management with remimazolam for a pediatric patient with Duchenne muscular dystrophy.
Medicine (Baltimore)
; 100(49): e28209, 2021 Dec 10.
Article
em En
| MEDLINE
| ID: mdl-34889305
ABSTRACT
RATIONALE With Duchenne muscular dystrophy (DMD) being the most common and most severe type of muscular dystrophy, DMD patients are at risk for complications from general anesthesia due to impaired cardiac and respiratory functions as the pathological condition progresses. In recent years, advances in multidisciplinary treatment have improved the prognosis of DMD patients, and the number of patients requiring surgery has increased. Remimazolam is a benzodiazepine derivative similar to midazolam. Its circulatory stability and the fact that it has an antagonist make it superior to propofol.There are no reports of pediatric patients with DMD undergoing total intravenous anesthesia with remimazolam. PATIENT CONCERNS A 4-year boy was scheduled for single-incision laparoscopic percutaneous extraperitoneal closure for inguinal hernia under general anesthesia, but the surgery was postponed because his serum creatine phosphokinase level was extremely high. DIAGNOSIS He was diagnosed with DMD. According to the results of the genetic test, exon deletion of the DMD gene was detected using multiplex ligation-dependent probe amplification, although he had no symptoms of DMD except for elevated serum levels of creatine phosphokinase, etc. INTERVENTION He was admitted for the same surgical purpose. Anesthesia was induced with 3âmg of intravenously administered remimazolam. He lost the ability to respond to verbal commands. After the intravenous administration of 100âµg of fentanyl, a continuous infusion of remifentanil (1.0âµg/kg/min) and remimazolam (15âmg/h) was started, and the endotracheal tube was inserted smoothly after the administration of 10âmg of rocuronium with which the muscle twitches disappeared in train-of-four monitoring. At the end of the surgery, 15âmg of flurbiprofen was administered intravenously. After surgery, we injected 40âmg of sugammadex to confirm a train-of-four count of 100%. OUTCOMES:
Although the dose of remimazolam was reduced to 5âmg/h 30 minutes before the end of the surgery, it took 20 minutes after the discontinuation of remimazolam for the patient to open his eyes upon verbal command. On postoperative Day 2, he was discharged from the hospital without any complications. LESSONS Remimazolam was shown to be safe to use for general anesthesia in a pediatric patient with DMD.
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Base de dados:
MEDLINE
Assunto principal:
Benzodiazepinas
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Bloqueio Neuromuscular
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Distrofia Muscular de Duchenne
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Anestésicos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article